Decreased A-to-I RNA editing as a source of keratinocytes' dsRNA in psoriasis

Recognition of dsRNA molecules activates the MDA5–MAVS pathway and plays a critical role in stimulating type-I interferon responses in psoriasis. However, the source of the dsRNA accumulation in psoriatic keratinocytes remains largely unknown. A-to-I RNA editing is a common co- or post-transcription...

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Publicado no:RNA
Main Authors: Shallev, Lea, Kopel, Eli, Feiglin, Ariel, Leichner, Gil S., Avni, Dror, Sidi, Yechezkel, Eisenberg, Eli, Barzilai, Aviv, Levanon, Erez Y., Greenberger, Shoshana
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959251/
https://ncbi.nlm.nih.gov/pubmed/29592874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.064659.117
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