DARPP-32 and t-DARPP promote non-small cell lung cancer growth through regulation of IKKα-dependent cell migration

Lung cancer is the leading cause of cancer-related death worldwide. Here we demonstrate that elevated expression of dopamine and cyclic adenosine monophosphate-regulated phosphoprotein, Mr 32000 (DARPP-32), and its truncated splice variant t-DARPP promote lung tumor growth, while abrogation of DARPP...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Alam, Sk. Kayum, Astone, Matteo, Liu, Ping, Hall, Stephanie R., Coyle, Abbygail M., Dankert, Erin N., Hoffman, Dane K., Zhang, Wei, Kuang, Rui, Roden, Anja C., Mansfield, Aaron S., Hoeppner, Luke H.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5959014/
https://ncbi.nlm.nih.gov/pubmed/29782621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0050-6
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