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Osteocalcin in the brain: from embryonic development to age-related decline in cognition

A remarkable, totally unexpected aspect of the bone-derived hormone osteocalcin is that it is necessary for both brain development and brain function in the mouse since its absence results in a profound deficit in spatial learning and memory and an exacerbation of anxiety-like behavior. The regulati...

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Detalhes bibliográficos
Publicado no:Nat Rev Endocrinol
Main Authors: Obri, Arnaud, Khrimian, Lori, Karsenty, Gerard, Oury, Franck
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5958904/
https://ncbi.nlm.nih.gov/pubmed/29376523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrendo.2017.181
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