HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a γ-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro

Castration-resistant prostate cancer (CRPC) continues to be a major challenge in the treatment of prostate cancer (PCa). The expression of hepatocyte cell adhesion molecule (HepaCAM), a novel tumor suppressor, is frequently downregulated or lost in PCa. Overactivated Notch signaling is involved in t...

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Pubblicato in:Int J Oncol
Autori principali: Du, Zhongbo, Li, Luo, Sun, Wei, Wang, Xiao, Zhang, Yao, Chen, Zhixiong, Yuan, Mengjuan, Quan, Zhen, Liu, Nanjing, Hao, Yanni, Li, Ting, Wang, Jinhua, Luo, Chunli, Wu, Xiaohou
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2018
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5958706/
https://ncbi.nlm.nih.gov/pubmed/29658567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2018.4370
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