Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB(2) Receptor Expression and Ligand Engagement in Human Cells

[Image: see text] Chemical tools and methods that report on G protein-coupled receptor (GPCR) expression levels and receptor occupancy by small molecules are highly desirable. We report the development of LEI121 as a photoreactive probe to study the type 2 cannabinoid receptor (CB(2)R), a promising...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Soethoudt, Marjolein, Stolze, Sara C., Westphal, Matthias V., van Stralen, Luuk, Martella, Andrea, van Rooden, Eva J., Guba, Wolfgang, Varga, Zoltan V., Deng, Hui, van Kasteren, Sander I., Grether, Uwe, IJzerman, Adriaan P., Pacher, Pal, Carreira, Erick M., Overkleeft, Herman S., Ioan-Facsinay, Andreea, Heitman, Laura H., van der Stelt, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5958339/
https://ncbi.nlm.nih.gov/pubmed/29420021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b11281
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados