A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration

Rhodopsin homeostasis is tightly coupled to rod photoreceptor cell survival and vision. Mutations resulting in the misfolding of rhodopsin can lead to autosomal dominant retinitis pigmentosa (adRP), a progressive retinal degeneration that currently is untreatable. Using a cell-based high-throughput...

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Pubblicato in:Nat Commun
Autori principali: Chen, Yuanyuan, Chen, Yu, Jastrzebska, Beata, Golczak, Marcin, Gulati, Sahil, Tang, Hong, Seibel, William, Li, Xiaoyu, Jin, Hui, Han, Yong, Gao, Songqi, Zhang, Jianye, Liu, Xujie, Heidari-Torkabadi, Hossein, Stewart, Phoebe L., Harte, William E., Tochtrop, Gregory P., Palczewski, Krzysztof
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5958115/
https://ncbi.nlm.nih.gov/pubmed/29773803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04261-1
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