A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration

Rhodopsin homeostasis is tightly coupled to rod photoreceptor cell survival and vision. Mutations resulting in the misfolding of rhodopsin can lead to autosomal dominant retinitis pigmentosa (adRP), a progressive retinal degeneration that currently is untreatable. Using a cell-based high-throughput...

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Publicado no:Nat Commun
Main Authors: Chen, Yuanyuan, Chen, Yu, Jastrzebska, Beata, Golczak, Marcin, Gulati, Sahil, Tang, Hong, Seibel, William, Li, Xiaoyu, Jin, Hui, Han, Yong, Gao, Songqi, Zhang, Jianye, Liu, Xujie, Heidari-Torkabadi, Hossein, Stewart, Phoebe L., Harte, William E., Tochtrop, Gregory P., Palczewski, Krzysztof
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5958115/
https://ncbi.nlm.nih.gov/pubmed/29773803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04261-1
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