Orientia tsutsugamushi uses two Ank effectors to modulate NF-κB p65 nuclear transport and inhibit NF-κB transcriptional activation

Orientia tsutsugamushi causes scrub typhus, a potentially fatal infection that threatens over one billion people. Nuclear translocation of the transcription factor, NF-κB, is the central initiating cellular event in the antimicrobial response. Here, we report that NF-κB p65 nuclear accumulation and...

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Vydáno v:PLoS Pathog
Hlavní autoři: Evans, Sean M., Rodino, Kyle G., Adcox, Haley E., Carlyon, Jason A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5957444/
https://ncbi.nlm.nih.gov/pubmed/29734393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007023
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