Randomized phase I trial HIV-CORE 003: Depletion of serum amyloid P component and immunogenicity of DNA vaccination against HIV-1

BACKGROUND: The failure of DNA vaccination in humans, in contrast to its efficacy in some species, is unexplained. Observational and interventional experimental evidence suggests that DNA immunogenicity may be prevented by binding of human serum amyloid P component (SAP). SAP is the single normal DN...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Borthwick, Nicola J., Lane, Thirusha, Moyo, Nathifa, Crook, Alison, Shim, Jung Min, Baines, Ian, Wee, Edmund G., Hawkins, Philip N., Gillmore, Julian D., Hanke, Tomáš, Pepys, Mark B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5957335/
https://ncbi.nlm.nih.gov/pubmed/29772028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0197299
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