Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

Esophageal adenocarcinoma (EAC) has a poor outcome, and targeted therapy trials have thus far been disappointing due to a lack of robust stratification methods. Whole-genome sequencing (WGS) analysis of 129 cases demonstrates that this is a heterogeneous cancer dominated by copy number alterations w...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Secrier, Maria, Li, Xiaodun, de Silva, Nadeera, Eldridge, Matthew D., Contino, Gianmarco, Bornschein, Jan, MacRae, Shona, Grehan, Nicola, O’Donovan, Maria, Miremadi, Ahmad, Yang, Tsun-Po, Bower, Lawrence, Chettouh, Hamza, Crawte, Jason, Galeano-Dalmau, Núria, Grabowska, Anna, Saunders, John, Underwood, Tim, Waddell, Nicola, Barbour, Andrew P., Nutzinger, Barbara, Achilleos, Achilleas, Edwards, Paul A. W., Lynch, Andy G., Tavaré, Simon, Fitzgerald, Rebecca C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5957269/
https://ncbi.nlm.nih.gov/pubmed/27595477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3659
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