Cattle with a precise, zygote-mediated deletion safely eliminate the major milk allergen beta-lactoglobulin

We applied precise  zygote-mediated genome editing to eliminate beta-lactoglobulin (BLG), a major allergen in cows’ milk. To efficiently generate LGB knockout cows, biopsied embryos were screened to transfer only appropriately modified embryos. Transfer of 13 pre-selected embryos into surrogate cows...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wei, Jingwei, Wagner, Stefan, Maclean, Paul, Brophy, Brigid, Cole, Sally, Smolenski, Grant, Carlson, Dan F., Fahrenkrug, Scott C., Wells, David N., Laible, Götz
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955954/
https://ncbi.nlm.nih.gov/pubmed/29769555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25654-8
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