Molecular details of dimerization kinetics reveal negligible populations of transient µ-opioid receptor homodimers at physiological concentrations

Various experimental and computational techniques have been employed over the past decade to provide structural and thermodynamic insights into G Protein-Coupled Receptor (GPCR) dimerization. Here, we use multiple microsecond-long, coarse-grained, biased and unbiased molecular dynamics simulations (...

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Foilsithe in:Sci Rep
Main Authors: Meral, Derya, Provasi, Davide, Prada-Gracia, Diego, Möller, Jan, Marino, Kristen, Lohse, Martin J., Filizola, Marta
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955887/
https://ncbi.nlm.nih.gov/pubmed/29769636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26070-8
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