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From a highly-disordered to a metastable state: Uncovering insights of α-synuclein

α-synuclein (αS) is a major constituent of Lewy bodies, the insoluble aggregates that are the hallmark of one of the most prevalent neurodegenerative disorders - Parkinson’s disease (PD). The vast majority of experiments in vitro and in vivo provide extensive evidence that a disordered monomeric for...

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Publicat a:ACS Chem Neurosci
Autors principals: Cote, Yoann, Delarue, Patrice, Scheraga, Harold A., Senet, Patrick, Maisuradze, Gia G.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955826/
https://ncbi.nlm.nih.gov/pubmed/29451381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00446
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