Mass spectrometry-based proteomics reveals potential roles of NEK9 and MAP2K4 in resistance to PI3K inhibitors in triple negative breast cancers

Activation of phosphoinositide 3-kinase (PI3K) signaling is frequently observed in triple-negative breast cancer (TNBC), yet PI3K inhibitors have shown limited clinical activity. To investigate intrinsic and adaptive mechanisms of resistance, we analyzed a panel of patient-derived xenograft models o...

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Publicat a:Cancer Res
Autors principals: Mundt, Filip, Rajput, Sandeep, Li, Shunqiang, Ruggles, Kelly, Mooradian, Arshag D., Mertins, Philipp, Gillette, Michael A., Krug, Karsten, Guo, Zhanfang, Hoog, Jeremy, Erdmann-Gilmore, Petra, Primeau, Tina, Huang, Shixia, Edwards, Dean P., Wang, Xiaowei, Wang, Xuya, Kawaler, Emily, Mani, D R., Clauser, Karl R., Gao, Feng, Luo, Jingqin, Davies, Sherri R., Johnson, Gary L., Huang, Kuan-lin, Yoon, Christopher J., Ding, Li, Fenyö, David, Ellis, Matthew J., Townsend, R. Reid, Held, Jason M., Carr, Steven A., Ma, Cynthia X.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955814/
https://ncbi.nlm.nih.gov/pubmed/29472518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1990
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