A Phase 1 Clinical Trial of Guadecitabine and Carboplatin In Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic And Pharmacodynamic Analyses

PURPOSE: Epigenetic changes are implicated in acquired resistance to platinum. Guadecitabine is a next-generation hypomethylating agent (HMA). Here we report the clinical results, along with pharmacokinetic (PK) and pharmacodynamic analyses of the phase 1 study of guadecitabine and carboplatin (G+C)...

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Udgivet i:Clin Cancer Res
Main Authors: Matei, Daniela, Ghamande, Sharad, Roman, Lynda, Secord, Angeles Alvarez, Nemunaitis, John, Markham, Merry Jennifer, Nephew, Kenneth P., Jueliger, Simone, Oganesian, Aram, Naim, Sue, Su, Xiang Yao, Keer, Harold, Azab, Mohammad, Fleming, Gini F
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955794/
https://ncbi.nlm.nih.gov/pubmed/29500276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3055
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