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CRISPR-Cas9-mediated generation of obese and diabetic mouse models
Mouse models of obesity (ob/ob) and diabetes (db/db) in which the leptin (Lep) and leptin receptor (Lepr) genes have been mutated, respectively, have contributed to a better understanding of human obesity and type 2 diabetes and to the prevention, diagnosis, and treatment of these metabolic diseases...
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| Veröffentlicht in: | Exp Anim |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Japanese Association for Laboratory Animal Science
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5955754/ https://ncbi.nlm.nih.gov/pubmed/29343656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.17-0123 |
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