CRISPR-Cas9-mediated generation of obese and diabetic mouse models

Mouse models of obesity (ob/ob) and diabetes (db/db) in which the leptin (Lep) and leptin receptor (Lepr) genes have been mutated, respectively, have contributed to a better understanding of human obesity and type 2 diabetes and to the prevention, diagnosis, and treatment of these metabolic diseases...

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Publicado en:Exp Anim
Autores principales: Roh, Jae-il, Lee, Junghoon, Park, Seong Uk, Kang, Young-Shin, Lee, Jaehoon, Oh, Ah-Reum, Choi, Dong Joon, Cha, Ji-Young, Lee, Han-Woong
Formato: Artigo
Lenguaje:Inglês
Publicado: Japanese Association for Laboratory Animal Science 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955754/
https://ncbi.nlm.nih.gov/pubmed/29343656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.17-0123
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