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Investigation of the importance of multidrug resistance-associated protein 4 (Mrp4/Abcc4) in the active efflux of anionic drugs across the blood–brain barrier

The importance of multidrug resistance-associated protein 4 (Mrp4/Abcc4) in limiting the penetration of Mrp4 substrate compounds into the central nervous system across the blood–brain barrier (BBB) was investigated using Mrp4(-/-) mice. Significant ATP-dependent uptake by MRP4 was observed for ochra...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Pharm Sci
Päätekijät: Kanamitsu, Kayoko, Kusuhara, Hiroyuki, Schuetz, John D., Takeuchi, Kenji, Sugiyama, Yuichi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955602/
https://ncbi.nlm.nih.gov/pubmed/28456721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2017.04.040
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