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Investigation of the importance of multidrug resistance-associated protein 4 (Mrp4/Abcc4) in the active efflux of anionic drugs across the blood–brain barrier
The importance of multidrug resistance-associated protein 4 (Mrp4/Abcc4) in limiting the penetration of Mrp4 substrate compounds into the central nervous system across the blood–brain barrier (BBB) was investigated using Mrp4(-/-) mice. Significant ATP-dependent uptake by MRP4 was observed for ochra...
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| Publicado no: | J Pharm Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5955602/ https://ncbi.nlm.nih.gov/pubmed/28456721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2017.04.040 |
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