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High-dimensional single-cell phenotyping reveals extensive haploinsufficiency
Haploinsufficiency, a dominant phenotype caused by a heterozygous loss-of-function mutation, has been rarely observed. However, high-dimensional single-cell phenotyping of yeast morphological characteristics revealed haploinsufficiency phenotypes for more than half of 1,112 essential genes under opt...
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| Pubblicato in: | PLoS Biol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5955526/ https://ncbi.nlm.nih.gov/pubmed/29768403 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005130 |
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