DGC-specific RHOA mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation

RHOA missense mutations exist specifically in diffuse type gastric cancers (DGC) and are considered one of the DGC driver genes, but it is not fully understood how RHOA mutations contribute to DGC development. Here we examined how RHOA mutations affect cancer cell survival and cell motility. We reve...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Nishizawa, Takashi, Nakano, Kiyotaka, Harada, Aya, Kakiuchi, Miwako, Funahashi, Shin-Ichi, Suzuki, Masami, Ishikawa, Shumpei, Aburatani, Hiroyuki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2018
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955407/
https://ncbi.nlm.nih.gov/pubmed/29796182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25269
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