DGC-specific RHOA mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation

RHOA missense mutations exist specifically in diffuse type gastric cancers (DGC) and are considered one of the DGC driver genes, but it is not fully understood how RHOA mutations contribute to DGC development. Here we examined how RHOA mutations affect cancer cell survival and cell motility. We reve...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Nishizawa, Takashi, Nakano, Kiyotaka, Harada, Aya, Kakiuchi, Miwako, Funahashi, Shin-Ichi, Suzuki, Masami, Ishikawa, Shumpei, Aburatani, Hiroyuki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2018
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955407/
https://ncbi.nlm.nih.gov/pubmed/29796182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25269
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