DGC-specific RHOA mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation

RHOA missense mutations exist specifically in diffuse type gastric cancers (DGC) and are considered one of the DGC driver genes, but it is not fully understood how RHOA mutations contribute to DGC development. Here we examined how RHOA mutations affect cancer cell survival and cell motility. We reve...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nishizawa, Takashi, Nakano, Kiyotaka, Harada, Aya, Kakiuchi, Miwako, Funahashi, Shin-Ichi, Suzuki, Masami, Ishikawa, Shumpei, Aburatani, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955407/
https://ncbi.nlm.nih.gov/pubmed/29796182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25269
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