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Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis

Preclinical models propose that the onset of psychosis is associated with hippocampal hyperactivity, thought to be driven by cortical GABAergic interneuron dysfunction and disinhibition of pyramidal neurons. Recent neuroimaging studies suggest that resting hippocampal perfusion is increased in subje...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Modinos, Gemma, Şimşek, Fatma, Azis, Matilda, Bossong, Matthijs, Bonoldi, Ilaria, Samson, Carly, Quinn, Beverly, Perez, Jesus, Broome, Matthew R, Zelaya, Fernando, Lythgoe, David J, Howes, Oliver D, Stone, James M, Grace, Anthony A, Allen, Paul, McGuire, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955214/
https://ncbi.nlm.nih.gov/pubmed/29440719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-017-0004-6
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