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Camptothecin induces G(2)/M phase arrest through the ATM-Chk2-Cdc25C axis as a result of autophagy-induced cytoprotection: Implications of reactive oxygen species
In the present study, we report that camptothecin (CPT) caused irreversible cell cycle arrest at the G(2)/M phase, and was associated with decreased levels of cell division cycle 25C (Cdc25C) and increased levels of cyclin B1, p21, and phospho-H3. Interestingly, the reactive oxygen species (ROS) inh...
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| Udgivet i: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Impact Journals LLC
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5955160/ https://ncbi.nlm.nih.gov/pubmed/29774099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24934 |
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