Camptothecin induces G(2)/M phase arrest through the ATM-Chk2-Cdc25C axis as a result of autophagy-induced cytoprotection: Implications of reactive oxygen species

In the present study, we report that camptothecin (CPT) caused irreversible cell cycle arrest at the G(2)/M phase, and was associated with decreased levels of cell division cycle 25C (Cdc25C) and increased levels of cyclin B1, p21, and phospho-H3. Interestingly, the reactive oxygen species (ROS) inh...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Prasad Tharanga Jayasooriya, Rajapaksha Gedara, Dilshara, Matharage Gayani, Neelaka Molagoda, Ilandarage Menu, Park, Cheol, Park, Sang Rul, Lee, Seungheon, Choi, Yung Hyun, Kim, Gi-Young
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955160/
https://ncbi.nlm.nih.gov/pubmed/29774099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24934
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