Silibinin sensitizes TRAIL-mediated apoptosis by upregulating DR5 through ROS-induced endoplasmic reticulum stress-Ca(2+)-CaMKII-Sp1 pathway

In this study, we addressed how silibinin enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in various cancer cells. Combined treatment with silibinin and TRAIL (silibinin/TRAIL) induced apoptosis accompanied by the activation of caspase-3, caspase-8, caspas...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Dilshara, Matharage Gayani, Jayasooriya, Rajapaksha Gedara Prasad Tharanga, Molagoda, Ilandarage Menu Neelaka, Jeong, Jin-Woo, Lee, Seungheon, Park, Sang Rul, Kim, Gi-Young, Choi, Yung Hyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828202/
https://ncbi.nlm.nih.gov/pubmed/29535810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23129
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