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The multifunctional protein YB-1 potentiates PARP1 activity and decreases the efficiency of PARP1 inhibitors

Y-box-binding protein 1 (YB-1) is a multifunctional cellular factor overexpressed in tumors resistant to chemotherapy. An intrinsically disordered structure together with a high positive charge peculiar to YB-1 allows this protein to function in almost all cellular events related to nucleic acids in...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Alemasova, Elizaveta E., Naumenko, Konstantin N., Kurgina, Tatyana A., Anarbaev, Rashid O., Lavrik, Olga I.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5955111/
https://ncbi.nlm.nih.gov/pubmed/29805738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25158
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