Molecular Mechanisms of PARP-1 Inhibitor 7-Methylguanine

7-Methylguanine (7-MG), a natural compound that inhibits DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1), can be considered as a potential anticancer drug candidate. Here we describe a study of 7-MG inhibition mechanism using molecular dynamics, fluorescence anisotropy and single-particle F...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Nilov, Dmitry, Maluchenko, Natalya, Kurgina, Tatyana, Pushkarev, Sergey, Lys, Alexandra, Kutuzov, Mikhail, Gerasimova, Nadezhda, Feofanov, Alexey, Švedas, Vytas, Lavrik, Olga, Studitsky, Vasily M.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7139824/
https://ncbi.nlm.nih.gov/pubmed/32245127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21062159
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