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Induction of the p53 Tumor Suppressor in Cancer Cells through Inhibition of Cap-Dependent Translation

The p53 tumor suppressor plays a critical role in protecting normal cells from malignant transformation. Development of small molecules to reactivate p53 in cancer cells has been an area of intense research. We previously identified an internal ribosomal entry site (IRES) within the 5′ untranslated...

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Bibliografiset tiedot
Julkaisussa:Mol Cell Biol
Päätekijät: Harris, Benjamin R. E., Wang, Defeng, Zhang, Ye, Ferrari, Marina, Okon, Aniekan, Cleary, Margot P., Wagner, Carston R., Yang, Da-Qing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2018
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954198/
https://ncbi.nlm.nih.gov/pubmed/29483299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00367-17
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