Salvianolic Acid A Ameliorates Arsenic Trioxide-Induced Cardiotoxicity Through Decreasing Cardiac Mitochondrial Injury and Promotes Its Anticancer Activity

Arsenic trioxide (ATO) is used as a therapeutic agent in the treatment of acute promyelocytic leukemia (APL). The therapeutic use of arsenic is limited due to its severe cardiovascular side effects. The cardio-protective effect of salvianolic acid A (Sal A) against ATO cardiotoxicity has been report...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Zhang, Jing-yi, Wang, Min, Wang, Rui-ying, Sun, Xiao, Du, Yu-yang, Ye, Jing-xue, Sun, Gui-bo, Sun, Xiao-bo
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954107/
https://ncbi.nlm.nih.gov/pubmed/29867492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00487
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