Calcium homeostasis and endoplasmic reticulum stress are involved in Salvianolic acid B-offered protection against cardiac toxicity of arsenic trioxide

Arsenic trioxide (ATO) is a potent anticancer agent used to treat acute promyelocytic leukemia. However, its cardiotoxicity limits ATO’s widespread clinical use. Previous studies demonstrated that ATO may aggravate Ca(2+) overload and promote endoplasmic reticulum stress (ERS). Salvianolic acid B (S...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, Jing-Yi, Zhang, Bin, Wang, Min, Wang, Wei, Liao, Ping, Sun, Gui-Bo, Sun, Xiao-Bo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722570/
https://ncbi.nlm.nih.gov/pubmed/29228618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22127
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