STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion

Enriched PD-L1 expression in cancer stem-like cells (CSCs) contributes to CSC immune evasion. However, the mechanisms underlying PD-L1 enrichment in CSCs remain unclear. Here, we demonstrate that epithelial–mesenchymal transition (EMT) enriches PD-L1 in CSCs by the EMT/β-catenin/STT3/PD-L1 signaling...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hsu, Jung-Mao, Xia, Weiya, Hsu, Yi-Hsin, Chan, Li-Chuan, Yu, Wen-Hsuan, Cha, Jong-Ho, Chen, Chun-Te, Liao, Hsin-Wei, Kuo, Chu-Wei, Khoo, Kay-Hooi, Hsu, Jennifer L., Li, Chia-Wei, Lim, Seung-Oe, Chang, Shih-Shin, Chen, Yi-Chun, Ren, Guo-xin, Hung, Mien-Chie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5954021/
https://ncbi.nlm.nih.gov/pubmed/29765039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04313-6
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