Pharmacodynamic modeling of cardiac biomarkers in breast cancer patients treated with anthracycline and trastuzumab regimens

Trastuzumab is associated with cardiotoxicity, manifesting as a decrease of the left-ventricular ejection fraction (LVEF). Administration of anthracyclines prior to trastuzumab increases risk of cardiotoxicity. High-sensitive troponin T and N-terminal-pro-brain natriuretic peptide (NT-proBNP) are mo...

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Publicado en:J Pharmacokinet Pharmacodyn
Autores principales: de Vries Schultink, Aurelia H. M., Boekhout, Annelies H., Gietema, Jourik A., Burylo, Artur M., Dorlo, Thomas P. C., van Hasselt, J. G. Coen, Schellens, Jan H. M., Huitema, Alwin D. R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2018
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953989/
https://ncbi.nlm.nih.gov/pubmed/29429038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-018-9579-8
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