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Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis

BACKGROUND: Fibrotic diseases result from an exuberant response to chronic inflammation. Myelofibrosis is the end result of inflammation in bone, caused by an inflammatory process triggered by production of abnormal myeloid cells driven by mutations affecting the JAK–STAT pathway. Inflammatory cytok...

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Detalles Bibliográficos
Publicado en:J Exp Pharmacol
Autores principales: Al-Fayoumi, Suliman, Hashiguchi, Taishi, Shirakata, Yuka, Mascarenhas, John, Singer, Jack W
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953271/
https://ncbi.nlm.nih.gov/pubmed/29785143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JEP.S150729
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