Identification of Serine 119 as an Effective Inhibitor Binding Site of M. tuberculosis Ubiquitin-like Protein Ligase PafA Using Purified Proteins and M. smegmatis

Owing to the spread of multidrug resistance (MDR) and extensive drug resistance (XDR), there is a pressing need to identify potential targets for the development of more-effective anti-M. tuberculosis (Mtb) drugs. PafA, as the sole Prokaryotic Ubiquitin-like Protein ligase in the Pup-proteasome Syst...

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Bibliographische Detailangaben
Veröffentlicht in:EBioMedicine
Hauptverfasser: Jiang, He-Wei, Czajkowsky, Daniel M., Wang, Tao, Wang, Xu-De, Wang, Jia-bin, Zhang, Hai-Nan, Liu, Cheng-Xi, Wu, Fan-Lin, He, Xiang, Xu, Zhao-Wei, Chen, Hong, Guo, Shu-Juan, Li, Yang, Bi, Li-Jun, Deng, Jiao-Yu, Xie, Jin, Pei, Jian-Feng, Zhang, Xian-En, Tao, Sheng-Ce
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952411/
https://ncbi.nlm.nih.gov/pubmed/29622495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.03.025
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