HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction

Anti-retroviral therapy successfully suppresses HIV-1 infection, but fails to provide a cure. During infection Type 1 IFNs normally play an essential role in viral clearance, but in vivo IFN-α only has a modest impact on HIV-1 infection, suggesting its possible targeting by HIV. Here, we report that...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Gargan, Siobhan, Ahmed, Suaad, Mahony, Rebecca, Bannan, Ciaran, Napoletano, Silvia, O'Farrelly, Cliona, Borrow, Persephone, Bergin, Colm, Stevenson, Nigel J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952252/
https://ncbi.nlm.nih.gov/pubmed/29580840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.03.006
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