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Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension

BACKGROUND: The importance of nitric oxide (NO) in hypoxic pulmonary hypertension has been demonstrated using nitric oxide synthase (NOS) knockout mice. In that model NO from endothelial NOS (eNOS) plays a central role in modulating pulmonary vascular tone and attenuating hypoxic pulmonary hypertens...

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Published in:Respir Res
Main Authors: Fagan, Karen A, Morrissey, Brian, Fouty, Brian W, Sato, Koichi, Harral, Julie Wright, Morris, Kenneth G, Hoedt-Miller, Marloes, Vidmar, Shanda, McMurtry, Ivan F, Rodman, David M
Format: Artigo
Language:Inglês
Published: BMC 2001
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Research
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC59521/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11686901/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/rr74
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