Convergent Loss of ABC Transporter Genes From Clostridioides difficile Genomes Is Associated With Impaired Tyrosine Uptake and p-Cresol Production

We report the frequent, convergent loss of two genes encoding the substrate-binding protein and the ATP-binding protein of an ATP-binding cassette (ABC) transporter from the genomes of unrelated Clostridioides difficile strains. This specific genomic deletion was strongly associated with the reduced...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Steglich, Matthias, Hofmann, Julia D., Helmecke, Julia, Sikorski, Johannes, Spröer, Cathrin, Riedel, Thomas, Bunk, Boyke, Overmann, Jörg, Neumann-Schaal, Meina, Nübel, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951980/
https://ncbi.nlm.nih.gov/pubmed/29867812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.00901
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