Granulocyte-Derived Extracellular Vesicles Activate Monocytes and Are Associated With Mortality in Intensive Care Unit Patients

To understand how extracellular vesicle (EV) subtypes differentially activate monocytes, a series of in vitro studies were performed. We found that plasma-EVs biased monocytes toward an M1 profile. Culturing monocytes with granulocyte-, monocyte-, and endothelial-EVs induced several pro-inflammatory...

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發表在:Front Immunol
Main Authors: Danesh, Ali, Inglis, Heather C., Abdel-Mohsen, Mohamed, Deng, Xutao, Adelman, Avril, Schechtman, Kenneth B., Heitman, John W., Vilardi, Ryan, Shah, Avani, Keating, Sheila M., Cohen, Mitchell J., Jacobs, Evan S., Pillai, Satish K., Lacroix, Jacques, Spinella, Philip C., Norris, Philip J.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2018
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951932/
https://ncbi.nlm.nih.gov/pubmed/29867942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00956
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