Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer

Hyperactivation of Wnt and Ras-MAPK signalling are common events in development of colorectal adenomas. Further progression from adenoma-to-carcinoma is frequently associated with 20q gain and overexpression of Aurora kinase A (AURKA). Interestingly, AURKA has been shown to further enhance Wnt and R...

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Foilsithe in:Sci Rep
Main Authors: Jacobsen, Annika, Bosch, Linda J. W., Martens-de Kemp, Sanne R., Carvalho, Beatriz, Sillars-Hardebol, Anke H., Dobson, Richard J., de Rinaldis, Emanuele, Meijer, Gerrit A., Abeln, Sanne, Heringa, Jaap, Fijneman, Remond J. A., Feenstra, K. Anton
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951826/
https://ncbi.nlm.nih.gov/pubmed/29760449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24982-z
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