Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide

Selective modification of native proteins in live cells is one of the central challenges in recent chemical biology. As a unique bioorthogonal approach, ligand-directed chemistry recently emerged, but the slow kinetics limits its scope. Here we successfully overcome this obstacle using N-acyl-N-alky...

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Vydáno v:Nat Commun
Hlavní autoři: Tamura, Tomonori, Ueda, Tsuyoshi, Goto, Taiki, Tsukidate, Taku, Shapira, Yonatan, Nishikawa, Yuki, Fujisawa, Alma, Hamachi, Itaru
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951806/
https://ncbi.nlm.nih.gov/pubmed/29760386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04343-0
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