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Isotonic Designs for Phase I Trials in Partially Ordered Groups
BACKGROUND/AIMS: Dose finding trials can be conducted such that patients are first stratified into multiple risk groups before doses are allocated. The risk groups are often completely ordered in that, for a fixed dose, the probability of toxicity is monotonically increasing across groups. In some t...
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| Vydáno v: | Clin Trials |
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| Hlavní autor: | |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5951616/ https://ncbi.nlm.nih.gov/pubmed/28776422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774517722760 |
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