Site-Directed Glycosylation of Peptide/Protein with Homogeneous O-Linked Eukaryotic N-Glycans

Here we report a facile and efficient method for site-directed glycosylation of peptide/protein. The method contains two sequential steps: generation of a GlcNAc-O-peptide/protein, and subsequent ligation of a eukaryotic N-glycan to the GlcNAc moiety. A pharmaceutical peptide, glucagon-like peptide-...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Wu, Zhigang, Jiang, Kuan, Zhu, Hailiang, Ma, Cheng, Yu, Zaikuan, Li, Lei, Guan, Wanyi, Liu, Yunpeng, Zhu, He, Chen, Yanyi, Li, Shanshan, Li, Jing, Cheng, Jiansong, Zhang, Lianwen, Wang, Peng George
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951161/
https://ncbi.nlm.nih.gov/pubmed/27529638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.6b00385
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