Cryo-EM structure of Escherichia coli σ(70) RNA polymerase and promoter DNA complex revealed a role of σ non-conserved region during the open complex formation

First step of gene expression is transcribing the genetic information stored in DNA to RNA by the transcription machinery including RNA polymerase (RNAP). In Escherichia coli, a primary σ(70) factor forms the RNAP holoenzyme to express housekeeping genes. The σ(70) contains a large insertion between...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Narayanan, Anoop, Vago, Frank S., Li, Kunpeng, Qayyum, M. Zuhaib, Yernool, Dinesh, Jiang, Wen, Murakami, Katsuhiko S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949986/
https://ncbi.nlm.nih.gov/pubmed/29581236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002161
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