Cryo-EM structure of Escherichia coli σ(70) RNA polymerase and promoter DNA complex revealed a role of σ non-conserved region during the open complex formation

First step of gene expression is transcribing the genetic information stored in DNA to RNA by the transcription machinery including RNA polymerase (RNAP). In Escherichia coli, a primary σ(70) factor forms the RNAP holoenzyme to express housekeeping genes. The σ(70) contains a large insertion between...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Narayanan, Anoop, Vago, Frank S., Li, Kunpeng, Qayyum, M. Zuhaib, Yernool, Dinesh, Jiang, Wen, Murakami, Katsuhiko S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Gene Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949986/
https://ncbi.nlm.nih.gov/pubmed/29581236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002161
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