Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ovarian cancer cells and endothelial cells

BACKGROUND: Epithelial ovarian cancer (EOC) is characterized by exacerbated angiogenesis regulated by proangiogenic and growth factors. Nerve growth factor (NGF) is overexpressed in EOC where it promotes proliferation as well as survival and is considered a proangiogenic factor. Metformin, a drug co...

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Detalhes bibliográficos
Publicado no:Ther Adv Med Oncol
Main Authors: Garrido, Maritza P., Vera, Carolina, Vega, Margarita, Quest, Andrew F.G., Romero, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949935/
https://ncbi.nlm.nih.gov/pubmed/29774060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835918770984
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