Rho kinase and Na(+)/H(+) exchanger mediate endothelin‐1‐induced pulmonary arterial smooth muscle cell proliferation and migration

Excessive production of endothelin‐1 (ET‐1) has been observed in almost all forms of pulmonary hypertension. ET‐1, a highly potent vasoconstrictor, can also potentiate pulmonary arterial smooth muscle cell (PASMC) growth and migration, both of which contribute to the vascular remodeling that occurs...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Huetsch, John C., Walker, Jasmine, Undem, Clark, Lade, Julie, Yun, Xin, Baksh, Syeda, Jiang, Haiyang, Lai, Ning, Shimoda, Larissa A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949284/
https://ncbi.nlm.nih.gov/pubmed/29756391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13698
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