Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline

Repressive H3K27me3 and active H3K4me2/3 together form bivalent chromatin domains, molecular hallmarks of developmental potential. In the male germline, these domains are thought to persist into sperm to establish totipotency in the next generation. However, it remains unknown how H3K27me3 is establ...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Maezawa, So, Hasegawa, Kazuteru, Yukawa, Masashi, Kubo, Naoki, Sakashita, Akihiko, Alavattam, Kris G., Sin, Ho-Su, Kartashov, Andrey V., Sasaki, Hiroyuki, Barski, Artem, Namekawa, Satoshi H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2018
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949012/
https://ncbi.nlm.nih.gov/pubmed/29686098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804512115
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