Cre Recombinase Mediates the Removal of Bacterial Backbone to Efficiently Generate rSV40

Gene therapy has been shown to be a feasible approach to treat inherited disorders in vivo. Among the currently used viral vector systems, adeno-associated virus (AAV) vectors are the most advanced and have been applied in patients successfully. An important drawback of non-integrating AAV vectors i...

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Bibliografske podrobnosti
izdano v:Mol Ther Methods Clin Dev
Main Authors: Shi, Xiaoxia, Ykema, Matthew Ryan, Hazenoot, Jaco, ten Bloemendaal, Lysbeth, Mancini, Irene, Odijk, Machteld, de Haan, Peter, Bosma, Piter J.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948228/
https://ncbi.nlm.nih.gov/pubmed/29766030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.02.010
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