Selective acetyl- and butyrylcholinesterase inhibitors reduce amyloid-β ex vivo activation of peripheral chemo-cytokines from Alzheimer’s disease subjects: exploring the cholinergic anti-inflammatory pathway

Increasing evidence suggests that the early pathogenesis of Alzheimer’s disease (AD) is driven by elevated production and/or reduced clearance of amyloid-β peptide (Aβ), which is derived from the larger Aβ precursor protein (APP). Aβ aggregates to form neurotoxic soluble oligomers that trigger a cas...

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Udgivet i:Curr Alzheimer Res
Main Authors: Reale, Marcella, Di Nicola, Marta, Velluto, Lucia, D’Angelo, Chiara, Costantini, Erica, Lahiri, Debomoy K., Kamal, Mohammad A., Yu, Qian-sheng, Greig, Nigel H.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947847/
https://ncbi.nlm.nih.gov/pubmed/24359497
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