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let-7 MicroRNA-Mediated Regulation of Shh Signaling and the Gene Regulatory Network Is Essential for Retina Regeneration

Upon injury, Müller glia cells of the zebrafish retina reprogram themselves to progenitor cells with stem cell characteristics. This necessity for retina regeneration is often compromised in mammals. We explored the significance of developmentally inevitable Sonic hedgehog signaling and found its ne...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Kaur, Simran, Gupta, Shivangi, Chaudhary, Mansi, Khursheed, Mohammad Anwar, Mitra, Soumitra, Kurup, Akshai Janardhana, Ramachandran, Rajesh
Format: Artigo
Langue:Inglês
Publié: Cell Press 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946716/
https://ncbi.nlm.nih.gov/pubmed/29719254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.002
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