Inactivation of the tight junction gene CLDN11 by aberrant hypermethylation modulates tubulins polymerization and promotes cell migration in nasopharyngeal carcinoma

BACKGROUND: Aberrant hypermethylation of cellular genes is a common phenomenon to inactivate genes and promote tumorigenesis in nasopharyngeal carcinoma (NPC). METHODS: Methyl binding domain (MBD)-ChIP sequencing of NPC cells, microarray data of NPC biopsies and gene ontology analysis were conducted...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Li, Hsin-Pai, Peng, Chen-Ching, Wu, Chih-Ching, Chen, Chien-Hsun, Shih, Meng-Jhe, Huang, Mei-Yuan, Lai, Yi-Ru, Chen, Yung-Li, Chen, Ting-Wen, Tang, Petrus, Chang, Yu-Sun, Chang, Kai-Ping, Hsu, Cheng-Lung
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946489/
https://ncbi.nlm.nih.gov/pubmed/29747653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0754-y
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