Effect of the S‐nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma

RATIONALE: Patients with asthma demonstrate depletion of the endogenous bronchodilator GSNO and upregulation of GSNOR. OBJECTIVES: An exploratory proof of concept clinical study of N6022 in mild asthma to determine the potential bronchoprotective effects of GSNOR inhibition. Mechanistic studies aime...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Immun Inflamm Dis
Asıl Yazarlar: Que, Loretta G., Yang, Zhonghui, Lugogo, Njira L., Katial, Rohit K., Shoemaker, Steven A., Troha, Janice M., Rodman, David M., Tighe, Robert M., Kraft, Monica
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946144/
https://ncbi.nlm.nih.gov/pubmed/29642282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iid3.220
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