Point Mutation of a Non-Elastase-Binding Site in Human α1-Antitrypsin Alters Its Anti-Inflammatory Properties

INTRODUCTION: Human α1-antitrypsin (hAAT) is a 394-amino acid long anti-inflammatory, neutrophil elastase inhibitor, which binds elastase via a sequence-specific molecular protrusion (reactive center loop, RCL; positions 357–366). hAAT formulations that lack protease inhibition were shown to maintai...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lior, Yotam, Zaretsky, Mariana, Ochayon, David E., Lotysh, Diana, Baranovski, Boris M., Schuster, Ronen, Guttman, Ofer, Aharoni, Amir, Lewis, Eli C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946014/
https://ncbi.nlm.nih.gov/pubmed/29780379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00759
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